Selective association of the methyl-CpG binding protein MBD2 with the silent p14/p16 locus in human neoplasia
DNA methylation of tumor suppressor genes is a common feature of human cancer. The cyclin-dependent kinase inhibitor gene p16/Ink4A is hypermethylated in a wide range of malignant tissues and the p14/ARF gene located 20 kb upstream on chromosome 9p21 is also methylated in carcinomas. p14/ARF (ARF, a...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33151/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11309512/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.101617298 |
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