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Drosophila cyclin D/Cdk4 regulates mitochondrial biogenesis and aging and sensitizes animals to hypoxic stress

Drosophila cyclin D (CycD) is the single fly ortholog of the mammalian cyclin D1 and promotes both cell cycle progression and cellular growth. However, little is known about how CycD promotes cell growth. We show here that CycD/Cdk4 hyperactivity leads to increased mitochondrial biogenesis (mitobiog...

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Sonraí Bibleagrafaíochta
Main Authors: Icreverzi, Amalia, Flor de la Cruz, Aida, Van Voorhies, Wayne A, Edgar, Bruce A
Formáid: Artigo
Teanga:Inglês
Foilsithe: Landes Bioscience 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315095/
https://ncbi.nlm.nih.gov/pubmed/22293404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.11.3.19062
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