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Mouse model for probing tumor suppressor activity of protein phosphatase 2A in diverse signaling pathways
Evidence that protein phosphatase 2A (PP2A) is a tumor suppressor in humans came from the discovery of mutations in the genes encoding the Aα and Aβ subunits of the PP2A trimeric holoenzymes, Aα-B-C and Aβ-B-C. One point mutation, Aα-E64D, was found in a human lung carcinoma. It renders Aα specifica...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3315090/ https://ncbi.nlm.nih.gov/pubmed/22262169 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.11.3.19057 |
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