Pyridoxine inhibits endothelial NOS uncoupling induced by oxidized low-density lipoprotein via the PKCα signalling pathway in human umbilical vein endothelial cells

BACKGROUND AND PURPOSE: One key mechanism for endothelial dysfunction is endothelial NOS (eNOS) uncoupling, whereby eNOS generates superoxide (O(2)(•−)) rather than NO. We explored the effect of pyridoxine on eNOS uncoupling induced by oxidized low-density lipoprotein (ox-LDL) in human umbilical vei...

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Hoofdauteurs: Xie, Liping, Liu, Zhen, Lu, Hui, Zhang, Wen, Mi, Qiongyu, Li, Xiaozhen, Tang, Yan, Chen, Qi, Ferro, Albert, Ji, Yong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Blackwell Publishing Ltd 2012
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Research Papers
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315046/
https://ncbi.nlm.nih.gov/pubmed/21797845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01607.x
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