Structural Dynamics Associated with Intermediate Formation in an Archetypal Conformational Disease

In conformational diseases, native protein conformers convert to pathological intermediates that polymerize. Structural characterization of these key intermediates is challenging. They are unstable and minimally populated in dynamic equilibria that may be perturbed by many analytical techniques. We...

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Hoofdauteurs: Nyon, Mun Peak, Segu, Lakshmi, Cabrita, Lisa D., Lévy, Géraldine R., Kirkpatrick, John, Roussel, Benoit D., Patschull, Anathe O.M., Barrett, Tracey E., Ekeowa, Ugo I., Kerr, Richard, Waudby, Christopher A., Kalsheker, Noor, Hill, Marian, Thalassinos, Konstantinos, Lomas, David A., Christodoulou, John, Gooptu, Bibek
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cell Press 2012
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314904/
https://ncbi.nlm.nih.gov/pubmed/22405009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.01.012
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