Structural Dynamics Associated with Intermediate Formation in an Archetypal Conformational Disease

In conformational diseases, native protein conformers convert to pathological intermediates that polymerize. Structural characterization of these key intermediates is challenging. They are unstable and minimally populated in dynamic equilibria that may be perturbed by many analytical techniques. We...

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Detaylı Bibliyografya
Asıl Yazarlar: Nyon, Mun Peak, Segu, Lakshmi, Cabrita, Lisa D., Lévy, Géraldine R., Kirkpatrick, John, Roussel, Benoit D., Patschull, Anathe O.M., Barrett, Tracey E., Ekeowa, Ugo I., Kerr, Richard, Waudby, Christopher A., Kalsheker, Noor, Hill, Marian, Thalassinos, Konstantinos, Lomas, David A., Christodoulou, John, Gooptu, Bibek
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cell Press 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314904/
https://ncbi.nlm.nih.gov/pubmed/22405009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.01.012
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