Ranolazine improves cardiac diastolic dysfunction through modulation of myofilament calcium sensitivity

RATIONALE: Previously, we demonstrated that a deoxycorticosterone acetate (DOCA)-salt hypertensive mouse model produces cardiac oxidative stress and diastolic dysfunction with preserved systolic function. Oxidative stress has been shown to increase late inward sodium current (I(Na)), reducing the ne...

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Detalhes bibliográficos
Main Authors: Lovelock, Joshua D., Monasky, Michelle M., Jeong, Euy-Myoung, Lardin, Harvey A., Liu, Hong, Patel, Bindiya G., Taglieri, Domenico M., Gu, Lianzhi, Kumar, Praveen, Pokhrel, Narayan, Zeng, Dewan, Belardinelli, Luiz, Sorescu, Dan, Solaro, R. John, Dudley, Samuel C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314887/
https://ncbi.nlm.nih.gov/pubmed/22343711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.258251
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