Small Molecule Antagonists of the Wnt/Beta-Catenin Signaling Pathway Target Breast Tumor-Initiating Cells in a Her2/Neu Mouse Model of Breast Cancer

BACKGROUND: Recent evidence suggests that human breast cancer is sustained by a minor subpopulation of breast tumor-initiating cells (BTIC), which confer resistance to anticancer therapies and consequently must be eradicated to achieve durable breast cancer cure. METHODS/FINDINGS: To identify signal...

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Main Authors: Hallett, Robin M., Kondratyev, Maria K., Giacomelli, Andrew O., Nixon, Allison M. L., Girgis-Gabardo, Adele, Ilieva, Dora, Hassell, John A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314694/
https://ncbi.nlm.nih.gov/pubmed/22470504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033976
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