Ocular Application of the Kinin B(1) Receptor Antagonist LF22-0542 Inhibits Retinal Inflammation and Oxidative Stress in Streptozotocin-Diabetic Rats

PURPOSE: Kinin B(1) receptor (B(1)R) is upregulated in retina of Streptozotocin (STZ)-diabetic rats and contributes to vasodilation of retinal microvessels and breakdown of the blood-retinal barrier. Systemic treatment with B(1)R antagonists reversed the increased retinal plasma extravasation in STZ...

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Main Authors: Pouliot, Mylène, Talbot, Sébastien, Sénécal, Jacques, Dotigny, Florence, Vaucher, Elvire, Couture, Réjean
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314679/
https://ncbi.nlm.nih.gov/pubmed/22470485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033864
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