Pharmacogenetic Association of NOS3 Variants with Cardiovascular Disease in Patients with Hypertension: The GenHAT Study

Nitric oxide synthase 3 (NOS3) catalyzes production of NO in the endothelium and may play a role in cardiovascular disease (CVD). We assessed the pharmacogenetic associations of three NOS3 polymorphisms and three antihypertensive drugs with CVD outcomes. Hypertensive subjects (n = 30,280) from a mul...

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Главные авторы: Zhang, Xue, Lynch, Amy I., Davis, Barry R., Ford, Charles E., Boerwinkle, Eric, Eckfeldt, John H., Leiendecker-Foster, Catherine, Arnett, Donna K.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2012
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314599/
https://ncbi.nlm.nih.gov/pubmed/22470539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034217
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