β(1) Integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy

Integrin signaling critically contributes to the progression, growth, and therapy resistance of malignant tumors. Here, we show that targeting of β(1) integrins with inhibitory antibodies enhances the sensitivity to ionizing radiation and delays the growth of human head and neck squamous cell carcin...

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Autori principali: Eke, Iris, Deuse, Yvonne, Hehlgans, Stephanie, Gurtner, Kristin, Krause, Mechthild, Baumann, Michael, Shevchenko, Anna, Sandfort, Veit, Cordes, Nils
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314473/
https://ncbi.nlm.nih.gov/pubmed/22378044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI61350
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