The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice

The bioactive lysophospholipid mediator sphingosine-1-phosphate (S1P) promotes the egress of newly formed T cells from the thymus and the release of immature B cells from the bone marrow. It has remained unclear, however, where and how S1P is released. Here, we show that in mice, the S1P transporter...

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Autori principali: Fukuhara, Shigetomo, Simmons, Szandor, Kawamura, Shunsuke, Inoue, Asuka, Orba, Yasuko, Tokudome, Takeshi, Sunden, Yuji, Arai, Yuji, Moriwaki, Kazumasa, Ishida, Junji, Uemura, Akiyoshi, Kiyonari, Hiroshi, Abe, Takaya, Fukamizu, Akiyoshi, Hirashima, Masanori, Sawa, Hirofumi, Aoki, Junken, Ishii, Masaru, Mochizuki, Naoki
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314466/
https://ncbi.nlm.nih.gov/pubmed/22406534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI60746
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