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P14ARF inhibits human glioblastoma–induced angiogenesis by upregulating the expression of TIMP3
Malignant gliomas are the most common and the most lethal primary brain tumors in adults. Among malignant gliomas, 60%–80% show loss of P14ARF tumor suppressor activity due to somatic alterations of the INK4A/ARF genetic locus. The tumor suppressor activity of P14ARF is in part a result of its abili...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3314443/ https://ncbi.nlm.nih.gov/pubmed/22378045 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38596 |
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