Effect of the PTPN22 and INS Risk Genotypes on the Progression to Clinical Type 1 Diabetes After the Initiation of β-Cell Autoimmunity

We set out to analyze the role of two major non-HLA gene polymorphisms associated with type 1 diabetes (T1D), PTPN22 1858C/T and insulin gene INS−23 A/T in progression to clinical T1D after the appearance of β-cell autoimmunity. The study population comprised 249 children with HLA-associated T1D sus...

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Hlavní autoři: Lempainen, Johanna, Hermann, Robert, Veijola, Riitta, Simell, Olli, Knip, Mikael, Ilonen, Jorma
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2012
Témata:
Genetics/Genomes/Proteomics/Metabolomics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314352/
https://ncbi.nlm.nih.gov/pubmed/22357962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0386
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