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Targeted chemical-genetic regulation of protein stability in vivo
Loss and gain-of-function transgenic models are powerful tools for understanding gene function in vivo, but are limited in their ability to determine relative protein requirements. To determine cell-specific, temporal or dose requirements of complex pathways, new methodology is needed. This is parti...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3314227/ https://ncbi.nlm.nih.gov/pubmed/22444594 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2011.12.022 |
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