Human CD55 Expression Blocks Hyperacute Rejection and Restricts Complement Activation in Gal Knockout Cardiac Xenografts

BACKGROUND: Transgenic expression of human complement regulatory proteins (hCRPs) reduces the frequency of hyperacute rejection (HAR) in Gal-positive cardiac xenotransplantation. In this study we examine the impact of human CD55 (hCD55) expression on a Gal knock-out (GTKO) background using pig-to-pr...

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Main Authors: McGregor, Christopher G.A., Ricci, Davide, Miyagi, Naoto, Stalboerger, Paul G., Du, Zeji, Oehler, Elise A., Tazelaar, Henry D., Byrne, Guerard W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314133/
https://ncbi.nlm.nih.gov/pubmed/22391577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0b013e3182472850
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