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Structural Insights from Binding Poses of CCR2 and CCR5 with Clinically Important Antagonists: A Combined In Silico Study
Chemokine receptors are G protein-coupled receptors that contain seven transmembrane domains. In particular, CCR2 and CCR5 and their ligands have been implicated in the pathophysiology of a number of diseases, including rheumatoid arthritis and multiple sclerosis. Based on their roles in disease, th...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3314010/ https://ncbi.nlm.nih.gov/pubmed/22479344 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032864 |
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