Deletion of growth hormone receptor gene but not visceral fat removal decreases expression of apoptosis-related genes in the kidney—potential mechanism of lifespan extension

Mice homozygous for the targeted disruption of the growth hormone (GH) receptor (Ghr) gene (GH receptor knockout; GHRKO; KO) are hypoinsulinemic, highly insulin sensitive, normoglycemic, and long-lived. Visceral fat removal (VFR) is a surgical intervention which improves insulin signaling in normal...

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Hlavní autoři: Gesing, Adam, Masternak, Michal M., Wang, Feiya, Karbownik-Lewinska, Malgorzata, Bartke, Andrzej
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Netherlands 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3312636/
https://ncbi.nlm.nih.gov/pubmed/21431351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-011-9232-6
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