Opioid receptor internalization contributes to dermorphin-mediated antinociception

Microinjection of opioids into the ventrolateral periaqueductal gray (vlPAG) produces antinociception in part by binding to mu-opioid receptors (MOPrs). Although both high and low efficacy agonists produce antinociception, low efficacy agonists such as morphine produce limited MOPr internalization s...

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Bibliographische Detailangaben
Hauptverfasser: Macey, Tara A., Ingram, Susan L., Bobeck, Erin N., Hegarty, Deborah M., Aicher, Sue A., Arttamangkul, Seksiri, Morgan, Michael M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3312465/
https://ncbi.nlm.nih.gov/pubmed/20394808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2010.04.003
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