(13)C MRS Detection of Changes in Serine Isotopomers Reflects Changes in Mitochondrial Redox Status

The glycine cleavage system (GCS), the major pathway of glycine catabolism in liver, is found only in the mitochondria matrix and is regulated by the NAD(+)/NADH ratio. In conjunction with serine hydroxymethyltransferase, glycine forms the 1 and 2 positions of serine, while the 3 position is formed...

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Hlavní autoři: Johnson, C. Bryce, Tikunov, Andrey P., Lee, Haakil, Wolak, Justyna E., Pediaditakis, Peter, Romney, Doug A., Holmuhamedov, Ekhson, Gamcsik, Michael P., Macdonald, Jeffrey M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311781/
https://ncbi.nlm.nih.gov/pubmed/22190282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mrm.23296
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