Antitumor Agents 289. Design, Synthesis, and Anti-breast Cancer Activity in Vivo of 4-Amino-2H-benzo[h]chromen-2-one (ABO) and 4-Amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one (ATBO) Analogues with Improved Water Solubility()

Previously, we reported that 4-amino-2H-benzo[h]chromen-2-one (ABO) and 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one (ATBO) analogues, which were developed from the lead natural produce neo-tanshinlactone, are potent cytotoxic agents. In order to improve on their water solubility, the diamin...

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Detalhes bibliográficos
Main Authors: Dong, Yizhou, Nakagawa-Goto, Kyoko, Lai, Chin-Yu, Morris-Natschke, Susan L., Bastow, Kenneth F., Kim, Yoon, Lee, Eva Y.-H. P., Lee, Kuo-Hsiung
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311758/
https://ncbi.nlm.nih.gov/pubmed/22304236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np2007878
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