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Bub1 kinase and Sgo1 modulate chromatin structure and dynamics in response to changes in microtubule dynamics

BACKGROUND: Tension sensing of bi-oriented chromosomes is essential for the fidelity of chromosome segregation. The spindle assembly checkpoint (SAC) conveys lack of tension or attachment to the anaphase promoting complex. Components of the SAC (Bub1) phosphorylate histone H2A (S121) and recruit the...

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Autors principals: Haase, Julian, Stephens, Andrew, Verdaasdonk, Jolien, Yeh, Elaine, Bloom, Kerry
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311747/
https://ncbi.nlm.nih.gov/pubmed/22365852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2012.02.006
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