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Distinct antigen-presenting cells explain the cytokine bias of α-galactosylceramide variants in vivo
α-galactosylceramide (αGC) represents a new class of vaccine adjuvants and immunomodulators that stimulate NKT cells to secrete Th1 and Th2 cytokines. Synthetic variants with short or unsaturated acyl chains exhibit a striking Th2 bias in vivo but no evidence of defect in TCR signaling or stimulatio...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3311697/ https://ncbi.nlm.nih.gov/pubmed/22393151 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1102414 |
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