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Effects of familial hemiplegic migraine type 1 mutation T666M on voltage-gated calcium channel activities in trigeminal ganglion neurons

Familial hemiplegic migraine type 1 (FHM-1), a rare hereditary form of migraine with aura and hemiparesis, serves as a good model for exploring migraine pathophysiology. The FHM-1 gene encodes the pore-forming Ca(V)2.1 subunit of human P/Q-type voltage-gated Ca(2+) channels (VGCCs). Some FHM-1 mutat...

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Detalles Bibliográficos
Main Authors: Tao, Jin, Liu, Ping, Xiao, Zheman, Zhao, Hucheng, Gerber, Benjamin R., Cao, Yu-Qing
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311679/
https://ncbi.nlm.nih.gov/pubmed/22190617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00551.2011
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