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Local tetrahydrobiopterin administration augments reflex cutaneous vasodilation through nitric oxide-dependent mechanisms in aged human skin

Functional constitutive nitric oxide synthase (NOS) is required for full expression of reflex cutaneous vasodilation that is attenuated in aged skin. Both the essential cofactor tetrahydrobiopterin (BH(4)) and adequate substrate concentrations are necessary for the functional synthesis of nitric oxi...

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Autors principals: Stanhewicz, Anna E., Bruning, Rebecca S., Smith, Caroline J., Kenney, W. Larry, Holowatz, Lacy A.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311663/
https://ncbi.nlm.nih.gov/pubmed/22162527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.01257.2011
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