Polo-like kinase 1 (PLK1) inhibition suppresses cell growth and enhances radiation sensitivity in medulloblastoma cells

BACKGROUND: Medulloblastoma is the most common malignant brain tumor in children and remains a therapeutic challenge due to its significant therapy-related morbidity. Polo-like kinase 1 (PLK1) is highly expressed in many cancers and regulates critical steps in mitotic progression. Recent studies sug...

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Detalhes bibliográficos
Main Authors: Harris, Peter S, Venkataraman, Sujatha, Alimova, Irina, Birks, Diane K, Donson, Andrew M, Knipstein, Jeffrey, Dubuc, Adrian, Taylor, Michael D, Handler, Michael H, Foreman, Nicholas K, Vibhakar, Rajeev
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311601/
https://ncbi.nlm.nih.gov/pubmed/22390279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-80
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