BMP type II receptor deficiency confers resistance to growth inhibition by TGF-β in pulmonary artery smooth muscle cells: role of proinflammatory cytokines

Mutations in the bone morphogenetic protein (BMP) type II receptor (BMPR-II) underlie most cases of heritable pulmonary arterial hypertension (HPAH) and a significant proportion of sporadic cases. Pulmonary artery smooth muscle cells (PASMCs) from patients with pulmonary arterial hypertension (PAH)...

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Detalhes bibliográficos
Main Authors: Davies, Rachel J., Holmes, Alan M., Deighton, John, Long, Lu, Yang, Xudong, Barker, Lucy, Walker, Christoph, Budd, David C., Upton, Paul D., Morrell, Nicholas W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311534/
https://ncbi.nlm.nih.gov/pubmed/22227206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00309.2011
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