LPA stimulates intestinal DRA gene transcription via LPA2 receptor, PI3K/AKT, and c-Fos-dependent pathway

DRA (downregulated in adenoma) or SLC26A3 is the major apical anion exchanger mediating Cl(−) absorption in intestinal epithelial cells. Disturbances in DRA function and expression have been implicated in diarrheal conditions such as congenital chloride diarrhea and inflammatory bowel diseases. Prev...

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Autors principals: Singla, Amika, Kumar, Anoop, Priyamvada, Shubha, Tahniyath, Maliha, Saksena, Seema, Gill, Ravinder K., Alrefai, Waddah A., Dudeja, Pradeep K.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2012
Matèries:
Mucosal Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311307/
https://ncbi.nlm.nih.gov/pubmed/22159277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00172.2011
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