Invariant NKT Cells Drive Hepatic Cytokinic Microenvironment Favoring Efficient Granuloma Formation and Early Control of Leishmania donovani Infection

The development of inflammatory granulomas around infected Kupffer cells is necessary for hepatic parasite clearance during visceral leishmaniasis. Invariant NKT (iNKT) cells are predominant T cells in the mouse liver and can synthesize large quantities of IL-4 and IFN-γ, two cytokines involved in g...

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Autori principali: Robert-Gangneux, Florence, Drogoul, Anne-Sophie, Rostan, Octavie, Piquet-Pellorce, Claire, Cayon, Jérome, Lisbonne, Mariette, Herbelin, André, Gascan, Hugues, Guiguen, Claude, Samson, Michel, Gangneux, Jean-Pierre
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310876/
https://ncbi.nlm.nih.gov/pubmed/22457760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033413
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