Invariant NKT Cells Drive Hepatic Cytokinic Microenvironment Favoring Efficient Granuloma Formation and Early Control of Leishmania donovani Infection

The development of inflammatory granulomas around infected Kupffer cells is necessary for hepatic parasite clearance during visceral leishmaniasis. Invariant NKT (iNKT) cells are predominant T cells in the mouse liver and can synthesize large quantities of IL-4 and IFN-γ, two cytokines involved in g...

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Detalhes bibliográficos
Main Authors: Robert-Gangneux, Florence, Drogoul, Anne-Sophie, Rostan, Octavie, Piquet-Pellorce, Claire, Cayon, Jérome, Lisbonne, Mariette, Herbelin, André, Gascan, Hugues, Guiguen, Claude, Samson, Michel, Gangneux, Jean-Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310876/
https://ncbi.nlm.nih.gov/pubmed/22457760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033413
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