Invariant NKT Cells Drive Hepatic Cytokinic Microenvironment Favoring Efficient Granuloma Formation and Early Control of Leishmania donovani Infection

The development of inflammatory granulomas around infected Kupffer cells is necessary for hepatic parasite clearance during visceral leishmaniasis. Invariant NKT (iNKT) cells are predominant T cells in the mouse liver and can synthesize large quantities of IL-4 and IFN-γ, two cytokines involved in g...

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Autors principals: Robert-Gangneux, Florence, Drogoul, Anne-Sophie, Rostan, Octavie, Piquet-Pellorce, Claire, Cayon, Jérome, Lisbonne, Mariette, Herbelin, André, Gascan, Hugues, Guiguen, Claude, Samson, Michel, Gangneux, Jean-Pierre
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310876/
https://ncbi.nlm.nih.gov/pubmed/22457760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033413
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