Increasing peptide identifications and decreasing search times for ETD spectra by pre-processing and calculation of parent precursor charge

BACKGROUND: Electron Transfer Dissociation [ETD] can dissociate multiply charged precursor polypeptides, providing extensive peptide backbone cleavage. ETD spectra contain charge reduced precursor peaks, usually of high intensity, and whose pattern is dependent on its parent precursor charge. These...

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Main Authors: Sridhara, Viswanadham, Bai, Dina L, Chi, An, Shabanowitz, Jeffrey, Hunt, Donald F, Bryant, Stephen H, Geer, Lewis Y
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2012
Teme:
Methodology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310747/
https://ncbi.nlm.nih.gov/pubmed/22321509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1477-5956-10-8
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