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Identification of CYP2C19*4B: pharmacogenetic implications for drug metabolism including clopidogrel responsiveness
CYP2C19 is a principal enzyme involved in the bioactivation of the antiplatelet prodrug clopidogrel and common CYP2C19 loss-of-function alleles are associated with adverse cardiovascular events. To assess the impact of the CYP2C19*17 increased activity allele in the Ashkenazi Jewish (AJ) and Sephard...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3310336/ https://ncbi.nlm.nih.gov/pubmed/21358751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tpj.2011.5 |
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