Expression of podoplanin in human astrocytic brain tumors is controlled by the PI3K-AKT-AP-1 signaling pathway and promoter methylation

Recently, we found strong overexpression of the mucin-type glycoprotein podoplanin (PDPN) in human astrocytic brain tumors, specifically in primary glioblastoma multiforme (GB). In the current study, we show an inverse correlation between PDPN expression and PTEN levels in primary human GB and gliom...

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Hlavní autoři: Peterziel, Heike, Müller, Julia, Danner, Andreas, Barbus, Sebastian, Liu, Hai-Kun, Radlwimmer, Bernhard, Pietsch, Torsten, Lichter, Peter, Schütz, Günther, Hess, Jochen, Angel, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
Basic and Translational Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3309862/
https://ncbi.nlm.nih.gov/pubmed/22394497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nos055
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