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Intratumoral platelet aggregate formation in a murine preclinical glioma model depends on podoplanin expression on tumor cells
Binding of the sialomucin-like transmembrane glycoprotein podoplanin (PDPN) to the platelet receptor C-type lectin-like receptor 2 induces platelet activation and aggregation. In human high-grade gliomas, PDPN is highly expressed both in tumor cells and in tumor-associated astrocytes. In glioma pati...
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| Publicado en: | Blood Adv |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society of Hematology
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6457221/ https://ncbi.nlm.nih.gov/pubmed/30948364 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018015966 |
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