Intratumoral platelet aggregate formation in a murine preclinical glioma model depends on podoplanin expression on tumor cells

Binding of the sialomucin-like transmembrane glycoprotein podoplanin (PDPN) to the platelet receptor C-type lectin-like receptor 2 induces platelet activation and aggregation. In human high-grade gliomas, PDPN is highly expressed both in tumor cells and in tumor-associated astrocytes. In glioma pati...

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Gepubliceerd in:Blood Adv
Hoofdauteurs: Costa, Barbara, Eisemann, Tanja, Strelau, Jens, Spaan, Ingrid, Korshunov, Andrey, Liu, Hai-Kun, Bugert, Peter, Angel, Peter, Peterziel, Heike
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2019
Onderwerpen:
Thrombosis and Hemostasis
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6457221/
https://ncbi.nlm.nih.gov/pubmed/30948364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018015966
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