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Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma

FTY720 is a sphingosine analogue that down regulates expression of sphingosine-1-phosphate receptors and causes apoptosis of multiple tumor cell types, including glioma cells. This study examined the effect of FTY720 on brain tumor stem cells (BTSCs) derived from human glioblastoma (GBM) tissue. FTY...

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Detalhes bibliográficos
Main Authors: Estrada-Bernal, Adriana, Palanichamy, Kamalakannan, Ray Chaudhury, Abhik, Van Brocklyn, James R.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3309856/
https://ncbi.nlm.nih.gov/pubmed/22351749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nos005
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