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Coupling of Ci-VSP Modules Requires a Combination of Structure and Electrostatics within the Linker

The voltage-sensitive phosphatase Ci-VSP consists of an intracellular phosphatase domain (PD) coupled to a transmembrane voltage-sensor domain (VSD). Depolarization triggers the selective dephosphorylation of phosphoinositides. However, the molecular mechanisms of coupling are still elusive. To clar...

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Detalhes bibliográficos
Main Authors: Hobiger, Kirstin, Utesch, Tillmann, Mroginski, Maria Andrea, Friedrich, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3309284/
https://ncbi.nlm.nih.gov/pubmed/22455914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.02.027
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