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Coupling of Ci-VSP Modules Requires a Combination of Structure and Electrostatics within the Linker
The voltage-sensitive phosphatase Ci-VSP consists of an intracellular phosphatase domain (PD) coupled to a transmembrane voltage-sensor domain (VSD). Depolarization triggers the selective dephosphorylation of phosphoinositides. However, the molecular mechanisms of coupling are still elusive. To clar...
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Main Authors: | , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
The Biophysical Society
2012
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3309284/ https://ncbi.nlm.nih.gov/pubmed/22455914 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.02.027 |
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