CYP2D6 Genotype and Tamoxifen Response in Postmenopausal Women with Endocrine-Responsive Breast Cancer: The Breast International Group 1-98 Trial

BACKGROUND: Adjuvant tamoxifen therapy is effective for postmenopausal women with endocrine-responsive breast cancer. Cytochrome P450 2D6 (CYP2D6) enzyme metabolizes tamoxifen to clinically active metabolites, and CYP2D6 polymorphisms may adversely affect tamoxifen efficacy. In this study, we invest...

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Main Authors: Regan, Meredith M., Leyland-Jones, Brian, Bouzyk, Mark, Pagani, Olivia, Tang, Weining, Kammler, Roswitha, Dell’Orto, Patrizia, Biasi, Maria Olivia, Thürlimann, Beat, Lyng, Maria B., Ditzel, Henrik J., Neven, Patrick, Debled, Marc, Maibach, Rudolf, Price, Karen N., Gelber, Richard D., Coates, Alan S., Goldhirsch, Aron, Rae, James M., Viale, Giuseppe
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2012
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3309132/
https://ncbi.nlm.nih.gov/pubmed/22395644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djs125
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