5-Lipoxygenase Deficiency Impairs Innate and Adaptive Immune Responses during Fungal Infection

5-lipoxygenase-derived products have been implicated in both the inhibition and promotion of chronic infection. Here, we sought to investigate the roles of endogenous 5-lipoxygenase products and exogenous leukotrienes during Histoplasma capsulatum infection in vivo and in vitro. 5-LO deficiency led...

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Detalhes bibliográficos
Main Authors: Secatto, Adriana, Rodrigues, Lilian Cataldi, Serezani, Carlos Henrique, Ramos, Simone Gusmão, Dias-Baruffi, Marcelo, Faccioli, Lúcia Helena, Medeiros, Alexandra I.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308949/
https://ncbi.nlm.nih.gov/pubmed/22448213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031701
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