The Leukotriene B(4)/BLT(1) Axis Is a Key Determinant in Susceptibility and Resistance to Histoplasmosis

The bioactive lipid mediator leukotriene B(4) (LTB(4)) greatly enhances phagocyte antimicrobial functions against a myriad of pathogens. In murine histoplasmosis, inhibition of the LT-generating enzyme 5-lypoxigenase (5-LO) increases the susceptibility of the host to infection. In this study, we inv...

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Detalhes bibliográficos
Main Authors: Secatto, Adriana, Soares, Elyara Maria, Locachevic, Gisele Aparecida, Assis, Patricia Aparecida, Paula-Silva, Francisco Wanderlei Garcia, Serezani, Carlos Henrique, de Medeiros, Alexandra Ivo, Faccioli, Lúcia Helena
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897419/
https://ncbi.nlm.nih.gov/pubmed/24465479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0085083
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