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CD4(+ )CD25(+ )FoxP3(+ )regulatory T cells suppress cytotoxicity of CD8(+ )effector T cells: implications for their capacity to limit inflammatory central nervous system damage at the parenchymal level
BACKGROUND: CD4(+ )CD25(+ )forkhead box P3 (FoxP3)(+ )regulatory T cells (T reg cells) are known to suppress adaptive immune responses, key control tolerance and autoimmunity. METHODS: We challenged the role of CD4(+ )T reg cells in suppressing established CD8(+ )T effector cell responses by using t...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3308921/ https://ncbi.nlm.nih.gov/pubmed/22373353 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-41 |
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