CD4(+ )CD25(+ )FoxP3(+ )regulatory T cells suppress cytotoxicity of CD8(+ )effector T cells: implications for their capacity to limit inflammatory central nervous system damage at the parenchymal level

BACKGROUND: CD4(+ )CD25(+ )forkhead box P3 (FoxP3)(+ )regulatory T cells (T reg cells) are known to suppress adaptive immune responses, key control tolerance and autoimmunity. METHODS: We challenged the role of CD4(+ )T reg cells in suppressing established CD8(+ )T effector cell responses by using t...

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Hauptverfasser: Göbel, Kerstin, Bittner, Stefan, Melzer, Nico, Pankratz, Susann, Dreykluft, Angela, Schuhmann, Michael K, Meuth, Sven G, Wiendl, Heinz
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308921/
https://ncbi.nlm.nih.gov/pubmed/22373353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-41
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