The Growth-Suppressive Function of the Polycomb Group Protein Polyhomeotic Is Mediated by Polymerization of Its Sterile Alpha Motif (SAM) Domain

Polyhomeotic (Ph), a member of the Polycomb Group (PcG), is a gene silencer critical for proper development. We present a previously unrecognized way of controlling Ph function through modulation of its sterile alpha motif (SAM) polymerization leading to the identification of a novel target for tuni...

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Bibliografske podrobnosti
Main Authors: Robinson, Angela K., Leal, Belinda Z., Chadwell, Linda V., Wang, Renjing, Ilangovan, Udayar, Kaur, Yogeet, Junco, Sarah E., Schirf, Virgil, Osmulski, Pawel A., Gaczynska, Maria, Hinck, Andrew P., Demeler, Borries, McEwen, Donald G., Kim, Chongwoo A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Protein Structure and Folding
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308824/
https://ncbi.nlm.nih.gov/pubmed/22275371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.336115
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