The Growth-Suppressive Function of the Polycomb Group Protein Polyhomeotic Is Mediated by Polymerization of Its Sterile Alpha Motif (SAM) Domain

Polyhomeotic (Ph), a member of the Polycomb Group (PcG), is a gene silencer critical for proper development. We present a previously unrecognized way of controlling Ph function through modulation of its sterile alpha motif (SAM) polymerization leading to the identification of a novel target for tuni...

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Detalhes bibliográficos
Main Authors: Robinson, Angela K., Leal, Belinda Z., Chadwell, Linda V., Wang, Renjing, Ilangovan, Udayar, Kaur, Yogeet, Junco, Sarah E., Schirf, Virgil, Osmulski, Pawel A., Gaczynska, Maria, Hinck, Andrew P., Demeler, Borries, McEwen, Donald G., Kim, Chongwoo A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308824/
https://ncbi.nlm.nih.gov/pubmed/22275371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.336115
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