The Vital Role of Polymerase ζ and REV1 in Mutagenic, but Not Correct, DNA Synthesis across Benzo[a]pyrene-dG and Recruitment of Polymerase ζ by REV1 to Replication-stalled Site

The DNA synthesis across DNA lesions, termed translesion synthesis (TLS), is a complex process influenced by various factors. To investigate this process in mammalian cells, we examined TLS across a benzo[a]pyrene dihydrodiol epoxide-derived dG adduct (BPDE-dG) using a plasmid bearing a single BPDE-...

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Bibliographic Details
Main Authors: Hashimoto, Keiji, Cho, Youngjin, Yang, In-Young, Akagi, Jun-ichi, Ohashi, Eiji, Tateishi, Satoshi, de Wind, Niels, Hanaoka, Fumio, Ohmori, Haruo, Moriya, Masaaki
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
DNA and Chromosomes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308759/
https://ncbi.nlm.nih.gov/pubmed/22303021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.331728
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