Aberrant splicing of the hRasGRP4 transcript and decreased levels of this signaling protein in the peripheral blood mononuclear cells in a subset of patients with rheumatoid arthritis

INTRODUCTION: An unidentified population of peripheral blood mononuclear cells (PBMCs) express Ras guanine nucleotide releasing protein 4 (RasGRP4). The aim of our study was to identify the cells in human blood that express hRasGRP4, and then to determine if hRasGRP4 was altered in any patient with...

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Hlavní autoři: Hashimoto, Toko, Yasuda, Shinsuke, Koide, Hideyuki, Kataoka, Hiroshi, Horita, Tetsuya, Atsumi, Tatsuya, Koike, Takao
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2011
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308084/
https://ncbi.nlm.nih.gov/pubmed/21933395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3470
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