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FADD cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase cascade

Granzyme M (GzmM), an orphan Gzm, is constitutively and abundantly expressed in innate effector natural killer cells. We previously demonstrated that GzmM induces caspase (casp)-dependent apoptosis and cytochrome c release from mitochondria. We also resolved the crystal structure for GzmM and genera...

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Detaylı Bibliyografya
Asıl Yazarlar: Wang, S, Xia, P, Shi, L, Fan, Z
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2012
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307975/
https://ncbi.nlm.nih.gov/pubmed/21979465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.130
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