INHIBITION OF MYCOLIC ACID TRANSPORT ACROSS THE MYCOBACTERIUM TUBERCULOSIS PLASMA MEMBRANE

New chemotherapeutics active against multidrug-resistant Mycobacterium tuberculosis (M. tb) are urgently needed. We report on the identification of an adamantyl urea compound displaying potent bactericidal activity against M. tb and a unique mode of action, namely the abolition of the translocation...

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Autors principals: Grzegorzewicz, Anna E., Pham, Ha, Gundi, Vijay A. K. B., Scherman, Michael S., North, Elton J., Hess, Tamara, Jones, Victoria, Gruppo, Veronica, Born, Sarah E. M., Korduláková, Jana, Chavadi, Sivagami Sundaram, Morisseau, Christophe, Lenaerts, Anne J., Lee, Richard E., McNeil, Michael R., Jackson, Mary
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307863/
https://ncbi.nlm.nih.gov/pubmed/22344175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.794
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