INHIBITION OF MYCOLIC ACID TRANSPORT ACROSS THE MYCOBACTERIUM TUBERCULOSIS PLASMA MEMBRANE

New chemotherapeutics active against multidrug-resistant Mycobacterium tuberculosis (M. tb) are urgently needed. We report on the identification of an adamantyl urea compound displaying potent bactericidal activity against M. tb and a unique mode of action, namely the abolition of the translocation...

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Hlavní autoři: Grzegorzewicz, Anna E., Pham, Ha, Gundi, Vijay A. K. B., Scherman, Michael S., North, Elton J., Hess, Tamara, Jones, Victoria, Gruppo, Veronica, Born, Sarah E. M., Korduláková, Jana, Chavadi, Sivagami Sundaram, Morisseau, Christophe, Lenaerts, Anne J., Lee, Richard E., McNeil, Michael R., Jackson, Mary
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307863/
https://ncbi.nlm.nih.gov/pubmed/22344175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.794
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