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Enantioselective Pictet-Spengler Reactions of Isatins for the Synthesis of Spiroindolones
[Image: see text] The condensation cyclization between isatins and 5-methoxy tryptamine catalyzed by chiral phosphoric acids provides spirooxindole tetrahydro-β-carboline products in excellent yields (up to 99%) and enantioselectivity (up to 98:2 er). A comparison of catalysts provides insight for t...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3307811/ https://ncbi.nlm.nih.gov/pubmed/22442499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2011.08.071 |
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