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Histone hyperacetylation can induce unfolding of the nucleosome core particle.

A direct correlation exists between the level of histone H4 hyperacetylation induced by sodium butyrate and the extent to which nucleosomes lose their compact shape and become elongated (62.0% of the particles have a length/width ratio over 1.6; overall mean in the length/width ratio = 1.83 +/- 0.48...

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Publicat a:Nucleic Acids Res
Autors principals: Oliva, R, Bazett-Jones, D P, Locklear, L, Dixon, G H
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 1990
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC330759/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2339060/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/18.9.2739
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