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Loss of DNA-binding and new transcriptional trans-activation function in polyomavirus large T-antigen with mutation of zinc finger motif.

A putative zinc finger in polyomavirus large T-antigen was investigated. We were unable to demonstrate unequivocally a requirement for zinc in specific DNA-binding using the chelating agent 1, 10-phenanthroline. An involvement of the putative zinc finger in specific DNA-binding was nevertheless sugg...

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Bibliographische Detailangaben
Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Bergqvist, A, Nilsson, M, Bondeson, K, Magnusson, G
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 1990
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC330756/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2160069/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/18.9.2715
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