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Itraconazole Side Chain Analogues: Structure–Activity Relationship Studies for Inhibition of Endothelial Cell Proliferation, Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) Glycosylation, and Hedgehog Signaling

[Image: see text] Itraconazole is an antifungal drug that was recently found to possess potent antiangiogenic activity and anti-hedgehog (Hh) pathway activity. To search for analogues of itraconazole with greater potency and to understand the structure–activity relationship in both antiangiogenic an...

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Bibliografiske detaljer
Main Authors: Shi, Wei, Nacev, Benjamin A., Aftab, Blake T., Head, Sarah, Rudin, Charles M., Liu, Jun O.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307530/
https://ncbi.nlm.nih.gov/pubmed/21936514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200944b
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